Showing posts with label diabetes. Show all posts
Showing posts with label diabetes. Show all posts

Friday, January 13, 2012

Hormone discovered - now no exercise needed?

Big News flash - the discovery of a hormone which gives the benefits of exercising without exercising.

 "Just take a pill and it will be like we exercised?" asked one newscaster of Dr Steven Garner who was not associated with the study.  The doctor answered affirmatively, explaining that it switches the "bad fat" to "good fat".  "If you want to do without exercise, you would only would take this pill for 10 weeks!" continued the doctor.

"Wouldn't there be other benefits of exercise though that this hormone would not provide?" The newscaster asked.  Dr Garner admitted it did not build up muscle mass.  And when the newscaster asked how much this pill would cost, Dr Garner suggested it might be very expensive because only one pharmaceutical has the patent.

I am a strong believer in "if it's too good to be true, it probably isn't" so I investigated.  An article by Bloomberg, admitted the hormone had only been tested in mice.  That definitely, might be a problem as far as it working the same way in humans. For example, giving mice Leptin makes them slim and it was once touted as the magic obesity curing hormone yet it was very disappointing in human trials.  For some reason, Leptin doesn't have the same effect on humans as it did on the mice.  Whatever the case, the announcement that it would even be effective, let alone safe in humans was very premature.

The reality is first of all, it's unproven whether it's safe or effective in humans and Dr Garner on Fox News using buzz phrases like "all natural" and "no KNOWN side effects" is code for "we haven't really tested it and won't know about its safety or effectiveness until we market it and people live or drop dead."  

Secondly, the greatest benefit from cardio exercise is exercising the heart and no pill will do that.

Bottom line, unless you trust the pharmaceuticals with your life, pass on this one and don't throw out your treadmills or bicycles.

More than likely, this headline was more about obtaining funding for the scientists rather than a real breakthrough and nothing does that so well as an eye catching, anti-obesity headline given to the news services.

Thursday, May 29, 2008

Even thin people get diabetes


An article carried on MSNBC (reprinted from the magazine "MensHealth") began with this promising headline.

Unfortunately, the headline of the article was probably the best and truest part. At least 33 percent of type II diabetics have never been fat in their lives.

But the article itself is typical from what can be expected from "MensHealth" magazine - MensHealth is a real pop science mag and not an accurate source at all. We KNOW that MSNBC would LIKELY NOT print a REALLY informative article about anything regarding obesity or diabetes and in that way, this article did not disappoint.

Most people will NOT slog through the verbiage which is very extensive ... I slogged through about 3/4 of it and then, decided the rest was more of the same.

The picture most people will take away with them from reading a couple of paragraphs, however, is the gaunt emaciated father (whom the author carefully avoids directly SAYING has diabetes by the way, so he may not even have the disease) who is in a nursing home and obviously suffering from Alzheimers. Well, news flash...Alzheimers is not only NOT related to diabetes (it's a gene also) but it's one of those diseases which fat people seldom get for some reason.... My FIL, a thin man who had diabetes and lost his legs to the illness, was intelligent and sharp up to the day he died just short of his 70th birthday. And my hubby's cousin is the same age as the author's gaunt father, has diabetes, takes medication and has a BMI which is in the high 50's or even the 60's - she travels all over the place, goes on cruises and doesn't even particularly adher to avoiding the sweets she's always liked. And she certainly is NOT senile in any way - she still lives on her own, having out lived her slim, health minded husband by several years, by the way.

Most people will just read the first couple of paragraphs and take with them the frightening picture of the senile father with Alzheimer's which the author has now connected with diabetes. But the media has that covered - most will scan the sub-headlines and get the message they want to convey anyway. One of these, is suggesting "low carb diet" for diabetes. But in reality that the reason even the ADA has NOT embraced low carb diets for diabetes is because there is NO PROOF that these diets are of ANY benefit to reducing sugar levels. It seems logical but people forget that EVERYTHING ends up glucose for energy. And I've seen my hubby, GG, a diabetic diagnosed 15 years ago, eat an all carb dinner and have a high reading in the morning and then the next night eat totally not only carb but fats and simple carbs and sugar and then have a low reading the following morning.

Diabetes sugar levels do apparently not rely on what you eat. They MAY rely on HOW MUCH you eat but the jury is still out on that one also. However there is certainly more observational evidence that eating less can bring down sugar levels but some of the slimmest diabetics have very high sugar levels so who really knows?

I have a friend who BELIEVEEEESSSS in the low carb way... she is an apostle for low carb eating. But her husband on much more metformin than GG even though HER husband is newly diagnosed, and who eats faithfully low carb, has sugar levels which range in the 300's (morning reading). She is not deterred however. Low carb dieting has not been kind of her figure either - she's got a high BMI even with never touching sugar and seems unable to lose the weight which has bugged her for decades. (We know she IS upset about her weight because she had weight loss surgery which was a health disaster for her, many years ago)

The article has a short blurb about exercise and this is about its only saving grace however, in the length of it, I bet most folks will have missed the paragraph about exercise so here it is for your convenience:

*** Just how powerful an antidote is exercise? A study published recently in the American Journal of Physiology — Endocrinology and Metabolism revealed that insulin resistance in rats decreased more from exercise than from taking metformin, the leading diabetes drug.***

That's it... pretty slim for what probably is the ONLY thing they know of to help control sugar levels besides medication. And by the way, they have a lot more than RAT studies suggesting the benefits of exercise for everyone and specifically for diabetics (i.e. intentional cardio).

More inaccuracies of the article? Diabetes is NOT the fastest growing disease. In fact, levels have DECREASED slightly in the last decade or so. How they are proclaiming that the incidence of diabetes has increased, may be because they are now counting everyone with a slightly elevated sugar level as in the realm of diabetic. Also they count women with gestational diabetes however, it has been observed that only about 50 percent of those with gestational diabetes actually come down with the illness. Often fat people even those with normal sugar levels are counted among the "pre diabetics".

The statement about diabetes greatly rising in incidence among children is erroneous also. People are BORN with insulin resistance - what is rising in incidence is our ability to DIAGNOSE insulin resistance in kids - something we were not able to do a couple of decades ago. But are we using this to get ALL KIDS to exercise or re-instituting P.E. on a daily basis in the schools? NOPE! It's just used as a scare tactic to sell diets and diet foods and impose diets on our children in their most vulnerable years.

What IS scary is not the "shockers" this article promises but rather than there is so much misinformation floating around about diabetes, it's frightening. Few doctors REQUIRE exercise of diabetics even though that's the only thing which has been shown to help.

Luckily we have medications which are excellent like metformin and do not have to rely on the "pancreas" burners like our parents were stuck with.

Many diabetics die of heart disease (which the media is quick to blame on the disease thus forgetting that heart disease in general IS the leading cause of death of ALL Americans not only diabetics!). And the greatest help in preventing or healing heart disease... The big "E" word, exercise.

Only 25 percent of Americans exercise cardio (which is what strengthens your heart) 3 times a week. Only 5 percent of Americans do daily cardio which is really what you need.

That (and not this inane article) is sobering and scary. Have YOU done your cardio today?

Wednesday, February 6, 2008

Why was the diabetes study ACCORD halted?

Halting a major study is not something done quickly because it can mean a drastic loss of money for those funding the study. But recently a huge study (named ACCORD) on aggressively treating diabetes by greatly lowering the blood sugar levels, greatly lowering the cholesterol and trigycerides and also blood pressure was halted.

The news stories were indefinite about why the study was halted and what WERE those treatments which proved to be too risky. I decided to research it.

First, I found that ACCORD has a website although nothing on there about halting the study!

I was curious about the treatments which turned out to be MORE dangerous than the standard treatment. From the protocol PDF, I found:

For blood sugar control: control group: metformin, and for the experimental group: glipozide and injected insulin (as an aggressive way to greatly lower A1C)

Lowering cholesterol and trigycerides: for the experimental group: higher doses of Zocor combined with fenofibrate (Tricor) and they did express some concern about the "adverse events" going in:

Because 40 mg of simvastatin may increase the risk for adverse events, particularly in the patients receiving fenofibrate, participants will be followed closely and CPK regularly measured.

The control group was just given Zocor. The experimental part was mixing Tricor with higher doses of Zocor. From websites on Tricor, I found the following general warnings:

Before taking fenofibrate, tell your doctor if you have
· liver disease,
· biliary cirrhosis,
· kidney disease,
· gallbladder disease,
· hypothyroidism (an underactive thyroid gland), or
· diabetes.

Fenofibrate apparently interacts adversely with the statin drugs and therein one suspects, lay one problem of this study:


Before taking fenofibrate, tell your doctor if you are taking any of the following medicines:
· an anticoagulant (blood thinner) such as warfarin (Coumadin);
· cyclosporine (Neoral, Sandimmune);
· lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), or cerivastatin (Baycol); or
· cholestyramine (Questran) or colestipol (Colestid).
• You may not be able to take fenofibrate, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the drugs listed above.
• Drugs other than those listed here may also interact with fenofibrate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

On another website, there are extensive lists of medications which can interact adversely with Tricor.

According to the ACCORD website, ACCORD was heavily funded by pharmaceuticals:

Abbott Laboratories (and Fournier Laboratories)
AstraZeneca LP
Aventis Pharmaceuticals, Inc.
GlaxoSmithKline Pharmaceuticals
King Pharmaceuticals, Inc.
MediSense Products (Division of Abbott Laboratories)
Merck & Company, Inc.
NetGroup Diabetic Services
Novartis Pharmaceuticals, Inc.
Novo Nordisk Pharmaceuticals, Inc.
Omron Healthcare, Inc.
According to one blog, the intensive treatment group (the experimental group) had more deaths than the controls:

The ACCORD (Action to Control Cardiovascular Risk in Diabetes) study enrolled 10,251 participants. Of these, 257 in the intensive treatment group have died, compared with 203 within the standard treatment group.


The researchers stated they did not know why they had a higher death toll in the "intensive treatment" group.

The interesting thing about this is that if you read the protocol PDF, on paper, their ideas seemed well based in former studies and logic. And yet, in reality that wasn't the case at all.

My suspicions are it had something to do with mixing the statin (zocor) with fenofibrate since on the fenofibrate website, that's in the warnings as a definite "no no".

The fact that the news stories about the study were so indefinite about the nature of the treatments, intrigued me enough to research it further...

Mystery kind of solved.